Publications

An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4.

An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4.

S. Bhaduri, M. K. E. Braza, S. Stanchev, M. Tauber, R. Al-Bawab, L. J. Liu, D. F. Trujillo, K. Solorio-Kirpichyan, A. Srivastava, J. Sanlley-Hernandez, A. J. O'Donoghue, M. K. Lemberg, R. Amaro, K. Strisovsky, S. E. Neal, J Biol Chem 10.1016/j.jbc.2025.108275, 108275 (2025).

Empowering STEM students: A university-wide mentorship program fostering retention and belonging.

Empowering STEM students: A university-wide mentorship program fostering retention and belonging.

S. Ravishankar, T. C. J. Spencer-Drakes, I. H. Fernandes, M. I. Hayes, S. Coopwood, I. Spencer, S. E. Neal, J Cell Physiol 239, e31348 (2024).

Proteotoxic stress and the ubiquitin proteasome system.

Proteotoxic stress and the ubiquitin proteasome system.

R. Kandel, J. Jung, S. Neal, Semin Cell Dev Biol 156, 107-120 (2024).

Juneteenth in STEMM and the barriers to equitable science.

Juneteenth in STEMM and the barriers to equitable science.

A. Mays, A. Byars-Winston, A. Hinton, Jr., A. G. Marshall, A. Kirabo, A. August, B. J. Marlin, B. Riggs, B. Tolbert, C. Wanjalla, C. Womack, C. S. Evans, C. Barnes, C. Starbird, C. Williams, C. Reynolds, C. Taabazuing, C. E. Cameron, D. D. Murray, D. Applewhite, D. J. Morton, D. Lee, D. W. Williams, D. Lynch, D. Brady, E. Lynch, F. U. N. Rutaganira, G. M. Silva, H. Shuler, I. A. Saboor, J. Davis, K. Dzirasa, L. Hammonds-Odie, L. Reyes, M. T. Sweetwyne, M. R. McReynolds, M. D. L. Johnson, N. A. Smith, N. Pittman, O. A. Ajijola, Q. Smith, R. A. S. Robinson, S. C. Lewis, S. A. Murray, S. Black, S. E. Neal, S. Andrisse, S. Townsend, S. M. Damo, T. N. Griffith, W. M. Lambert, W. M. Clemons, Jr., Cell 186, 2510-2517 (2023).

Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress.

Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress.

R. Kandel, J. Jung, D. Syau, T. Kuo, L. Songster, C. Horn, C. Chapman, A. Aguayo, S. Duttke, C. Benner, S. E. Neal, PLoS Biol 21, e3001950 (2023).

An ERAD-independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis.

An ERAD-independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis.

S. Bhaduri, A. Aguayo, Y. Ohno, M. Proietto, J. Jung, I. Wang, R. Kandel, N. Singh, I. Ibrahim, A. Fulzele, E. J. Bennett, A. Kihara, S. E. Neal, EMBO J 42, e112275 (2023).

The Role of the Rhomboid Superfamily in ER Protein Quality Control: From Mechanisms and Functions to Diseases.

The Role of the Rhomboid Superfamily in ER Protein Quality Control: From Mechanisms and Functions to Diseases.

S. Bhaduri, N. A. Scott, S. E. Neal, Cold Spring Harb Perspect Biol 15 (2023).

Quality Control: Maintaining molecular order and preventing cellular chaos.

Quality Control: Maintaining molecular order and preventing cellular chaos.

S. Neal, F. Ohtake, A. M. Cuervo, R. S. Hegde, U. Jakob, M. Lazarou, W. V. Gilbert, Z. J. Chen, S. A. Tooze, J. E. Haber, K. J. Walters, F. U. Hartl, Mol Cell 82, 1390-1397 (2022).

Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates.

Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates.

A. Nejatfard, N. Wauer, S. Bhaduri, A. Conn, S. Gourkanti, N. Singh, T. Kuo, R. Kandel, R. E. Amaro, S. E. Neal, Cell Rep 38, 110578 (2022).

Decoding Transcription Regulatory Mechanisms Associated with Coccidioides immitis Phase Transition Using Total RNA.

Decoding Transcription Regulatory Mechanisms Associated with Coccidioides immitis Phase Transition Using Total RNA.

S. H. Duttke, S. Beyhan, R. Singh, S. Neal, S. Viriyakosol, J. Fierer, T. N. Kirkland, J. E. Stajich, C. Benner, A. F. Carlin, mSystems 7, e0140421 (2022).

Assays for studying normal versus suppressive ERAD-associated retrotranslocation pathways in yeast.

Assays for studying normal versus suppressive ERAD-associated retrotranslocation pathways in yeast.

S. Bhaduri, S. E. Neal, STAR Protoc 2, 100640 (2021).

Inner-nuclear-membrane-associated degradation employs Dfm1-independent retrotranslocation and alleviates misfolded transmembrane-protein toxicity.

Inner-nuclear-membrane-associated degradation employs Dfm1-independent retrotranslocation and alleviates misfolded transmembrane-protein toxicity.

M. P. Flagg, M. A. Wangeline, S. R. Holland, S. H. Duttke, C. Benner, S. Neal, R. Y. Hampton, Mol Biol Cell 32, 521-537 (2021).

Impaired phosphatidylethanolamine metabolism activates a reversible stress response that detects and resolves mutant mitochondrial precursors.

Impaired phosphatidylethanolamine metabolism activates a reversible stress response that detects and resolves mutant mitochondrial precursors.

P. N. Sam, E. Calzada, M. G. Acoba, T. Zhao, Y. Watanabe, A. Nejatfard, J. C. Trinidad, T. E. Shutt, S. E. Neal, S. M. Claypool, iScience 24, 102196 (2021).

The role of rhomboid superfamily members in protein homeostasis: Mechanistic insight and physiological implications.

The role of rhomboid superfamily members in protein homeostasis: Mechanistic insight and physiological implications.

R. R. Kandel, S. E. Neal, Biochim Biophys Acta Mol Cell Res 1867, 118793 (2020).

HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation.

HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation.

S. Neal, D. Syau, A. Nejatfard, S. Nadeau, R. Y. Hampton, iScience 23, 101493 (2020).

Assays for protein retrotranslocation in ERAD.

Assays for protein retrotranslocation in ERAD.

S. Neal, S. H. Duttke, R. Y. Hampton, Methods Enzymol 619, 1-26 (2019).

The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.

The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.

S. Neal, P. A. Jaeger, S. H. Duttke, C. Benner, K. G. C, T. Ideker, R. Y. Hampton, Mol Cell 69, 306-320 e304 (2018).

Osm1 facilitates the transfer of electrons from Erv1 to fumarate in the redox-regulated import pathway in the mitochondrial intermembrane space.

Osm1 facilitates the transfer of electrons from Erv1 to fumarate in the redox-regulated import pathway in the mitochondrial intermembrane space.

S. E. Neal, D. V. Dabir, J. Wijaya, C. Boon, C. M. Koehler, Mol Biol Cell 28, 2773-2785 (2017).

A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates.

A Cdc48 "Retrochaperone" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates.

S. Neal, R. Mak, E. J. Bennett, R. Hampton, J Biol Chem 292, 3112-3128 (2017).

Direct and essential function for Hrd3 in ER-associated degradation.

Direct and essential function for Hrd3 in ER-associated degradation.

N. Vashistha, S. E. Neal, A. Singh, S. M. Carroll, R. Y. Hampton, Proc Natl Acad Sci U S A 113, 5934-5939 (2016).

Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway.

Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway.

S. E. Neal, D. V. Dabir, H. L. Tienson, D. M. Horn, K. Glaeser, R. R. Ogozalek Loo, A. Barrientos, C. M. Koehler, J Biol Chem 290, 20804-20814 (2015).

Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins.

Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins.

H. L. Tienson, D. V. Dabir, S. E. Neal, R. Loo, S. A. Hasson, P. Boontheung, S. K. Kim, J. A. Loo, C. M. Koehler, Mol Biol Cell 20, 3481-3490 (2009).